The NEO-500 is one of our flagship instruments for routine solution-state NMR experiments. It is equipped with a Bruker Avance IV NEO console and a 5 mm 1H/BB iProbe. The spectrometer runs on full-automation using a SampleXpress autosampler and provides a high-throughput screening capability for all routine and crude NMR samples. This instrument is accessible by new users upon completing the basic access training.